The most easy way to configure your mail client is to download to your computer and run Mail Client Automatic Configuration Script available in your Cpanel > Email Accounts > Set Up Mail Client.
But if this way is not available for you for some reasons, here Here is the most commonly used setup with SSL encryption for email exchange, just replace "domain.com" with your actual domain name.
Type:
POP3 (or IMAP if you want to store email IMAP (POP3 is considered to be outdated, while IMAP is more stable, plus allows to store emails server-side)
incoming server:
mail.domain.com
outgoing server:
mail.domain.com
username:
youraddress@domain.com
password:
The password you made in cPanel for the above email account when you created the email account.
...
Secure Password Authentication:
OffSelect This server requires an encrypted connection (SSL)
My Server Requires Authentication:
ON
Outgoing mail (SMTP) port
465
Incoming server port
993 for IMAP
995 for POP3
You may find it necessary to use your ISP's outgoing mail server if you can receive mail, but not send it.
However, before you call them and ask for their SMTP, try changing your SMTP port from the default 25 to 26. This is especially useful for those of you that travel and do not want to use webmail. Using port 26 should allow you to use your laptop and mail program wherever you may travel.
If that does not work, call Call your ISP and ask them for their SMTP outgoing mailserver and other SMTP settings, and use their SMTP settings even if they contradict our settings recommended above.
More information on how to send email when your ISP blocks port 25, or general "receiving mail but not able to send mail" information can be found at the URL below:I can't send email, but I can receive it
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